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Image Jane Austen's works with color illustrations.

Pride and Prejudice
Emma
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Image Alzheimer's disease and other neurodegenerative disorders may arise from a common pathogenic cascade: BDNF deficiency > miR-132 down-regulation > Tau level up > Hyperexcitability > Calcium overload. Hyperactive mTOR may increase Tau level, resulting in hyperexcitability. This novel mechanism is supported by the finding that rapamycin (a potent mTOR inhibitor) suppresses hyperexcitability. The model explains why mTOR plays a crucial role in aging.