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23. Example: Translocation of Bcr-Abl Genes

Example: Translocation of <i>Bcr-Abl</i> Genes


In chronic myelogenous leukemia, a translocation occurs between chromosomes 9 and 22. This rearrangement of genomic material creates a fusion gene call Bcr-Abl that produces a protein (tyrosine kinase) thought to promote the development of leukemia. The drug Gleevec blocks the activation of the Bcr-Abl protein.