Title Page

1. Normal Cell Communication

2. Cancer: A Communication Failure

3. Detecting the Troublemakers

4. Molecular Diagnostics

5. Gene Expression Patterns

6. Pause For a Science Lesson

7. Lesson 1: Genomic DNA and Genes

8. Lesson 2: Genes Express mRNA

9. Lesson 3: Expression Changes With Cell Type

10. Finding Genes With Microarrays

11. Finding Genes With Microarrays (cont.)

12. Using DNA Microarrays to Measure Gene Expression

13. Using DNA to Compare Cancer Cells to Normal Cells

14. Making Sense of the Data

15. Microarrays Come In Many Models

16. Cancer-Specific Gene Expression

17. Potential Markers for Metastasis

18. Subtyping Cancer

19. Lymphomas and Microarray Research

20. Microarray Predicts Survival

21. Finding New Drugs With Microarrays

22. HER-2/NEU Protein as Target

23. An Antibody Called Herceptin

24. Using Expression Patterns to Choose Treatments

25. SNPs Microarrays Check Drug Metabolism

26. Molecular Diagnostics and Proteomics

27. Proteomics Maps Protein Patterns

28. Proteomics Maps Protein Patterns (cont.)

29. Laser Capture Microdissection

30. Finding Subsets

31. Protein Patterns and Diagnosis

32. Importance of Diagnostic Test Sensitivity

33. Importance of Diagnostic Test Sensitivity (cont.)

34. Importance of Diagnostic Test Specificity

35. Importance of Diagnostic Test Specificity (cont.)

36. From Patterns to Screening Tool

37. From Known Samples to Serum Proteins

38. Molecular Mop

39. Serum Proteins Can Serve as Markers

40. Molecular Diagnostics Has Many Uses

41. In the Future

42. Clinical Trials: Making the Future the Present