Understanding AngiogenesisbyNational Cancer Institute Title Page 1. What Is Metastasis? 2. Metastasis Requires Angiogenesis 3. What Is Tumor Angiogenesis 4. Normal Angiogenesis in Children 5. Normal Angiogenesis in Adults 6. Angiogenesis and Vascular Endothelial Cells 7. Angiogenesis and Regulatory Proteins 8. Angiogenesis and Cancer 9. Without Angiogenesis, Tumor Growth Stops 10. With Angiogenesis, Tumor Growth Proceeds 11. What Prompts Angiogenesis? 12. Activators of Angiogenesis 13. The Angiogenesis Signaling Cascade 14. Endothelial Cell Activation 15. Inhibitors of Angiogenesis 16. Angiogenesis Inhibitors and Primary Tumors 17. Angiogenesis Inhibitors and Metastasis 18. Angiogenesis and Tumor Dormancy 19. Cancer in Angiogenesis-Deficient Mice 20. Angiogenesis Inhibitors in the Treatment of Human Cancer 21. Drugs That Inhibit Angiogenesis Directly 22. Old Drug With a New Use 23. Drugs That Block the Angiogenesis Signaling Cascade 24. Drugs That Block Extracellular Matrix Breakdown 25. Drugs with Other Mechanisms of Action 26. On to Clinical Trials
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