Title Page

1. What Are Estrogens?

2. Estrogen Target Tissues

3. Estrogen Receptors

4. Estrogen Receptors Trigger Gene Activation

5. Estrogen-Induced Changes in Cell Behavior

6. Estrogen-Induced Stimulation of Cell Proliferation

7. Estrogen and Cancer

8. Estrogen and Breast Cancer

9. Cancer Arises From DNA Mutations In Cells

10. Estrogen-Induced Proliferation of Existing Mutant Cells

11. Estrogen-Induced Proliferation and Spontaneous New Mutations

12. Estrogen and Uterine Cancer

13. Antiestrogens

14. SERMs

15. Tamoxifen and Cancer

16. Tamoxifen and Breast Cancer Treatment

17. Estrogen Receptor-Negative Breast Cancer

18. Tamoxifen and Breast Cancer Prevention

19. Tamoxifen as a Cause of Uterine Cancer

20. The Need for Better SERMs

21. Estrogen Replacement During Menopause

22. Estrogen Plus Progesterone Replacement

23. Search for the Perfect SERM

24. Raloxifene and the Prevention of Osteoporosis

25. Raloxifene and Risk of Invasive Breast Cancer