32. SNPs and Bladder Cancer Risk
SNPs are responsible for the existence of several different slow forms of the acetylator enzyme. In individuals with a slow acetylator, the arylamines remain in the liver for a longer time, and more of them are converted to precarcinogens rather than nonreactive compounds. Thus, individuals with slow acetylators may be at increased risk for bladder cancer because they are exposed to more carcinogens in the bladder.